Post by jeffs on Jan 6, 2006 22:10:53 GMT -5
Myelin Impairs CNS Remyelination by Inhibiting Oligodendrocyte Precursor Cell Differentiation
www.jneurosci.org/cgi/content/abstract/26/1/328
Mark R. Kotter, Wen-Wu Li, Chao Zhao, and Robin J. M. Franklin
Cambridge Centre for Brain Repair and Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom
Demyelination in the adult CNS can be followed by extensive repair. However, in multiple sclerosis, the differentiation of oligodendrocyte lineage cells present in demyelinated lesions is often inhibited by unknown factors. In this study, we test whether myelin debris, a feature of demyelinated lesions and an in vitro inhibitor of oligodendrocyte precursor differentiation, affects remyelination efficiency. See the complete article here: www.jneurosci.org/cgi/content/abstract/26/1/328
www.jneurosci.org/cgi/content/abstract/26/1/328
Mark R. Kotter, Wen-Wu Li, Chao Zhao, and Robin J. M. Franklin
Cambridge Centre for Brain Repair and Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom
Demyelination in the adult CNS can be followed by extensive repair. However, in multiple sclerosis, the differentiation of oligodendrocyte lineage cells present in demyelinated lesions is often inhibited by unknown factors. In this study, we test whether myelin debris, a feature of demyelinated lesions and an in vitro inhibitor of oligodendrocyte precursor differentiation, affects remyelination efficiency. See the complete article here: www.jneurosci.org/cgi/content/abstract/26/1/328